Cruciferous Vegetables Reduce Morphological Markers of Colon Cancer Risk in Dimethylhydrazine-Treated Rats
نویسندگان
چکیده
منابع مشابه
Glucosinolates from Cruciferous Vegetables for Cancer Chemoprevention
Prevention and/or protection against chemical carcinogens by phytochemicals present in extensively consumed glucosinolate-containing cruciferous vegetables is of great of interest, as they provide a safe and cost effective means of combating cancer. Extensive epidemiological studies revealed repeatedly an inverse relationship between cruciferous vegetable consumption and the incidence of cancer...
متن کاملCruciferous vegetables and colo-rectal cancer.
Cruciferous vegetables have been studied extensively for their chemoprotective effects. Although they contain many bioactive compounds, the anti-carcinogenic actions of cruciferous vegetables are commonly attributed to their content of glucosinolates. Glucosinolates are relatively biologically inert but can be hydrolysed to a range of bioactive compounds such as isothiocyanates (ITC) and indole...
متن کاملMorphological and Molecular Alterations in 1,2 Dimethylhydrazine and Azoxymethane Induced Colon Carcinogenesis in Rats
The dimethyhydrazine (DMH) or azoxymethane (AOM) model is a well-established, well-appreciated, and widely used model of experimental colon carcinogenesis. It has many morphological as well as molecular similarities to human sporadic colorectal cancer (CC), which are summarized and discussed in this paper. In addition, the paper combines present knowledge of morphological and molecular features...
متن کاملGenetics of colon carcinogenesis in mice treated with 1,2-dimethylhydrazine.
Genetic analysis of colon tumor induction by symmetrical 1,2-dimethylhydrazine (DMH) was undertaken in F1, F2, and reciprocal backcross hybrids derived from a cross between two inbred mouse strains, the 100% susceptible ICR/Ha and completely resistant C57BL/Ha. Mice, 12 to 14 weeks old, received 22 successive weekly s.c. injections of 0.35% aqueous solution of DMH buffered to pH 6.5. A dose of ...
متن کاملSurface changes in the descending colon of rats treated with dimethylhydrazine.
Male Sprague-Dawley rats were given weekly s.c. injections of 1,2-dimethylhydrazine (21 mg/kg) for period of up to 20 weeks. The descending colon of treated animals killed at 2 weekly intervals was examined for morphological change, over a 30-week period, after commencement of treatment using scanning electron microscopy, light microscopy, transmission electron microscopy, and freeze-fracture t...
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ژورنال
عنوان ژورنال: The Journal of Nutrition
سال: 2008
ISSN: 0022-3166,1541-6100
DOI: 10.1093/jn/138.3.526